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Emergency Contact 24h

0900 712 712

(3.23 CHF / min. from the Swiss landline, possibly additionally 8 Rp. / min. by network operator)

 
 

0900 712 713

(3.12 CHF / min. for calls from prepaid cell phones, possibly additionally 8 Rp. / min. by network operator)


Important Numbers

  • 144   Ambulance
  • 145   Tox Center (Poisoning)
  • 117   Police
  • 118   Fire Department

Kontakt Box

UKBB

University Children’s Hospital Basel
Spitalstrasse 33
4056 Basel
Switzerland

T +41 61 704 12 12
F +41 61 704 12 13

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For making an appointment or the postponement of an appointment, please contact polyclinic head office +41 61 704 12 20

 
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Developmental Immunology

Our laboratory has a long-standing research interest in lymphoid tissue inducer (LTi) cells, control of fetal and adult lineage commitment and adaptive immunity in secondary lymphoid organs and mucosal tissues. LTi cells belong to a recently discovered family of innate lymphoid cells (ILCs), which are characterized by the production of cytokines analogous to Th1, Th2 and Th17 cell subsets. ILCs became the focus of attention for their potential roles in early response to infection, autoimmune disorders, allergy, and tissue repair. The identification of pathways that promote ILC subset development is essential for better understanding how ILCs may contribute to pro- versus anti-inflammatory responses. We were able to identify IL-7, KitL, TSLP and Flt3 as important cytokines involved in the life cycle and differentiation of ILCs and in the development of lymphoid tissues. Using cytokine reporter mice, various genetically modified mouse strains and retroviral inducible gene delivery models (loss or gain of function) we have gained further insights into the regulation of ILCs.

Our research is now focusing on the origin, transcriptional control and the immune function of ILCs and related cell subsets in vivo. Environmental factors such as microbiota, AHR ligands and vitamins and also innate receptors and proinflammatory cytokines regulate growth, differentiation and survival of fetal and adult ILCs.

Dependent on the microenvironment, differences in the maturation and activation state of ILCs were observed, which may regulate the outcome of immune responses. The understanding of how the growing family of ILCs regulates innate and adaptive immunity will be vital for the discovery of new biomedical targets preventing inflammation and autoimmunity.

Main projects

  1. Transcriptional control of ILC development and function
  2. Interaction of ILCs with the adaptive immune system
  3. Response and production of cytokines by ILCs
  4. ILC-stroma interactions and tissue repair in immunodeficiency diseases
  5. ILC-driven immune regulation of mucosal inflammation and cancer
 

Group members

  • Edit Horvath, technician
  • Annick Peter, technician
  • Frank Lehmann, postdoc
  • Gleb Turchinovich, postdoc
  • Martha Gaio, administrative assistant
 

Emergencies

0900 712 712

(3.23 CHF/min. CH-landline, possibly additionally 8 Rp. / min. by network operator)

0900 712 713

(3.12 CHF/min. prepaid cell phones, possibly additionally 8 Rp. / min. by network operator)

Site Map

Contact

University Children’s Hospital Basel
Spitalstrasse 33
4056 Basel / Switzerland

T +41 61 704 12 12
F +41 61 704 12 13

 

Emergency

Contact

University Children’s Hospital Basel
Spitalstrasse 33
4056 Basel / Switzerland

T +41 61 704 12 12
F +41 61 704 12 13

© UKBB, 2018