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University Children’s Hospital Basel
Spitalstrasse 33
4056 Basel
Switzerland
T +41 61 704 12 12
The goal of our research group is to better
understand the transition from intra- to extra-uterine life and to examine
therapeutic strategies against transition failure. The process of vaginal birth
prepares the baby for the extra-uterine environment and, in comparison to
babies delivered by elective cesarean section, confers respiratory,
cardiovascular and immunological advantages to the newborn.
We investigate the
role of stress hormones during birth, including vasopressin/copeptin, the
causes and consequences of their release with a particular focus on breathing,
weight changes and pain experience in the newborn. In the case of birth
complications or premature delivery, e.g. a lack of oxygen (hypoxia-ischemia) can
damage the brain owing to long-lasting neurodevelopmental disabilities. Total
body hypothermia commenced shortly after birth is an effective therapy to
alleviate neuronal damage after perinatal hypoxia-ischemia but the underlying
molecular mechanisms of cold protection are poorly understood. Here we concentrate
on the two cold-inducible proteins RBM3 and CIRP, which are involved in
neuroplasticity and inflammation.
A second strategy for neuroprotection is the administration of erythropoietin. In an international multicenter randomized trial, enrolling preterm neonates with intraventricular hemorrhage or hemorrhagic parenchymal infarction, we test the effect of high-dose erythropoietin on neurodevelopmental outcome (www.eporepair.ch). Our studies are performed in close collaboration with other research groups of the UKBB, with the Department of Obstetrics and Gynecology (Prof. Lapaire) and the Department of Biomedicine (Prof. Guzman) of the University Hospital Basel, the Biozentrum (Prof. Kapfhammer) of the University of Basel, and the Universities of Zurich (PD Dr. Burkhardt) and Oxford (Prof. Slater).
Senior Physician Neonatology,
Research Group Leader
Prof. Dr. med. Sven Wellmann - HR - Our staff - UKBB an independent, university-wide competence center for pediatric and adolescent medicine. Contact us!
(3.23 CHF/min. CH-landline, possibly additionally 8 Rp. / min. by network operator)
(3.12 CHF/min. prepaid cell phones, possibly additionally 8 Rp. / min. by network operator)
University Children’s Hospital Basel
Spitalstrasse 33
4056 Basel / Switzerland
T +41 61 704 12 12
Contact
University Children’s Hospital Basel
Spitalstrasse 33
4056 Basel / Switzerland
T +41 61 704 12 12
Contact
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