Cleft lip and palate

We critically review our treatment procedures and therapeutic measures in order to offer a modern and effective treatment concept. Research studies show us which measures are really necessary for an optimal result and which can be dispensed with. This enables us to minimise the treatment burden for the child and family. At the same time, we conduct laboratory research to develop promising new techniques and treatment alternatives and co-operate with various laboratories in Switzerland and abroad.

Here you will find current publications of our research group for cleft lip and palate and facial malformations: mueller.medizin.unibas.ch

Selection of some clinical articles in specialised journals:

• Benitez BK, Brudnicki A, Surowiec Z, Singh RK, Nalabothu P, Schumann D, Mueller AA. Continuous Circular Closure in Unilateral Cleft Lip and Plate Repair in One Surgery, Journal of Cranio-Maxillofacial Surgery, 2021, https://www.sciencedirect.com/science/article/pii/S1010518221001839.
• Benitez B, Brudnicki A, Nalabothu P, von Jackowski J, Bruder E, Mueller AA. Histologic aspect of the curved vomerine mucosa in cleft lip and palate. The Cleft Palate-Craniofacial Journal 2021; https://doi.org/10.1177/10556656211031419.
• Nalabothu P, Benitez BK, Dalstra M, Verna C, Mueller AA. Three-Dimensional Morphological Changes of the True Cleft under Passive Presurgical Orthopaedics in Unilateral Cleft Lip and Palate: A Retrospective Cohort Study. J Clin Med. 2020;9(4):962. doi.org/10.3390/jcm9040962.
• Mueller AA. Less surgery and more biology. Bulletin of the Association of Parents of Cleft Children. 31st issue, February 2020. https://lkg-spalte.ch/wp-content/uploads/id_spalte_2020_31.pdf.
• Indri I, Rovito L, Codoni S, Zeilhofer HF. New therapeutic approaches in the treatment of patients with cleft palate. Cranio Facial Kinetic Science (CFKSc) & Functional Kinetic Science (FKSc). Logos. 2016; 24 (4):265-271.
• Mueller AA, Forraz N, Gueven S, Atzeni G, Degoul O, Pagnon-Minot A, Hartmann D, Martin I, Scherberich A, McGuckin C. Osteoblastic differentiation of Wharton jelly biopsy specimens and their mesenchymal stromal cells after serum-free culture. Plast Reconstr Surg. 2014 Jul;134(1):59e-69e https://www.ncbi.nlm.nih.gov/pubmed/25028857.
• Mueller AA, Kalak N, Schwenzer-Zimmerer K, Holsboer-Trachsler E, Brand S. Cortisol levels and sleep patterns in infants with OFC undergoing surgery. Neuropsychiatr Dis Treat, 2014 Oct 15;10:1965-72. https://www.ncbi.nlm.nih.gov/pubmed/?term=25342905.
• Mueller AA, Schumann D, Reddy RR, Schwenzer-Zimmerer K, Mueller-Gerbl M, Zeilhofer HF, Sailer H, Reddy GS. Intraoperative vascular anatomy, arterial blood flow velocity and microcirculation in uni- and bilateral cleft lip repair. Plast and Reconstr Surg. 2012;130 (5):1120-30 https://www.ncbi.nlm.nih.gov/pubmed/?term=23096613.
• Mueller AA, Zschokke I, Brand S, Hockenjos C, Zeilhofer HF, Schwenzer-Zimmerer. One-stage cleft repair outcome at age 6- to 18 years - a comparison to the Eurocleft study data. Br J Oral Maxillofac Surg. 2011 Dec;49(8):e67-71. https://www.ncbi.nlm.nih.gov/pubmed/?term=22551772.
• Schwenzer-Zimmerer K. Cleft lip and palate - only a surgical problem? Schweiz Med Forum 2011;11(46):824-829. http://medicalforum.ch/docs/smf/archiv/de/2011/2011-46/2011-46-240.pdf.
• Mueller AA, Paysan P, Schumacher R, Zeilhofer HF, Berg-Boerner BI, Maurer J, Vetter T, Schkommodau E, Juergens P, Schwenzer-Zimmerer K. Missing facial parts computed by a morphable model and transferred directly to a polyamide laser-sintered prosthesis: an innovation study. Br J Oral Maxillofac Surg. 2011;49(8):e67-71. https://www.ncbi.nlm.nih.gov/pubmed/?term=21458119.
• Schwenzer-Zimmerer K, Boerner BI, Schwenzer NF, Mueller AA, Juergens P, Ringenbach A, Schkommodau E, Zeilhofer HF. Facial acquisition by dynamic optical tracked laser imaging: a new approach. J Plast Reconstr Aesthet Surg. 2009;62(9):1181-6. https://www.ncbi.nlm.nih.gov/pubmed/?term=18602359.
• Brand S, Blechschmidt A, Mueller AA, Sader R, Schwenzer-Zimmerer K, Zeilhofer HF, Holsboer-Trachsler E. Psychosocial functioning and sleep patterns in children and adolescents with cleft lip and palate compared to healthy controls. Cleft Palate Craniofac J. 2009;46(2):124-35. https://www.ncbi.nlm.nih.gov/pubmed/?term=19254057.
• Mueller AA, Sader R, Honigmann K, Zeilhofer HF, Schwenzer-Zimmerer K. Central nervous malformation in presence of clefts reflect their developmental interplay. Int J Oral and Maxillofac Surg 2007; 36: 289-295 https://www.ncbi.nlm.nih.gov/pubmed/?term=17254751.
• Leiggener CS, Curtis R, Mueller AA, Pfluger D, Gogolewski S, Rahn BA. Influence of copolymer composition of polylactide implants on cranial bone regeneration. Biomaterials 2006; 27(2):202-7. https://www.ncbi.nlm.nih.gov/pubmed/?term=16026823.
• Mueller AA, Rahn BA, Gogolewski S, Leiggener CS. Early dural reaction to polylactide in cranial defects of rabbits. Pediatr Neurosurg 2005; 41(6):285-91. https://www.ncbi.nlm.nih.gov/pubmed/?term=16293947.
• Honigmann K. One-stage closure of uni- and bilateral cleft lip and palate. Br J Oral Maxillofac Surg 1996;34:214-9. https://www.ncbi.nlm.nih.gov/pubmed/?term=8818253.

Books:

• Codoni, S., Spirgi-Gantert, I., von, J. J., & Springer-Verlag GmbH. (2019). Function-orientated speech therapy: The influence of posture and movement on swallowing, speech and language.
• Masaracchia, R., Herzog-Isler, C., & Sader, R. A. (2005). Split feelings: Cleft lip, jaw and palate - a parents' guide. Zurich: Oesch.
• Honigmann, K. (1998). Cleft lip and palate: The Basel concept of a holistic approach. Bern: Verlag Hans Huber.
• Honigmann K. (1995). Centralised care of patients with cleft lip and palate. In: Oertli, D., & Laffer, U. (1995). Surgery from head to toe. Basel: Schwabe & Co.