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UKBB

University Children’s Hospital Basel
Spitalstrasse 33
4056 Basel
Switzerland

T +41 61 704 12 12
F +41 61 704 12 13

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Prof. Urs Frey, MD, PhD

Urs Frey

Medical Director UKBB,
Chief Physician Pediatrics,
Member of the Executive Board,
Research Group Leader

 

Personal data

Date of Birth

June 7, 1962

Nationality

Swiss

Marital Status

married, 2 children

Current positions

2019 - present

Chairman of the National Steering Board, Swiss Personalized Health Network

2015 - present

Individual member of the Swiss Academy of Medical Researchers

2010 - present

Medical Director, Chair of Pediatrics, University Children's Hospital, Basel

2016 - 2018

Vice President of the National Steering Board of the Swiss Personalised Health Network

2015 - 2018

Vice President Swiss PedNet

Education and training

1999

Ph.D. Bioengineering, Leicester University, Leicester, UK

1997

Specialisation - Child and Youth Medicine and Pulmonology, University of Bern, CH

1995

Specialisation - Pediatrics, University of Bern, CH

1990

MD, University of Bern, CH

Professional positions

2005 - 2010

Head of Department and Professor of Pediatric Pulmonolgy, University Hospital of Bern, CH

2001 - 2005

Consultant Pediatric Pulmonology, University Hospital of Bern, CH

1997 - 2001

SCORE Fellowship - Swiss National Society, University of Bern, CH

1994 - 1997

Fellowship - Swiss National Society, Leicester University, UK

1994

Fellowship - Swiss CF Society, Dept of Bopmedical Engineering, Boston University, Boston, USA

1990 - 1993

Clinical Training - Pediatrics, University of Bern, CH

1989 - 1990

Fellowship - Swiss National Society, University of Bern, Switzerland

Research experiences and grants

2018 - 2021

Swiss National Science Foundation 320030B-182871
The prospective Basel-Bern infant lung development birth cohort (BILD): Impact of air pollution on profibrotic and autophagy related mechanisms involved in the development of the respiratory system in infants.

2015 - 2018

Swiss National Science Foundation 320030-163311
The prospective Basel-Bern infant lung development birth cohort (BILD): Integrating the impact of genetic and environmental factors on trajectories of respiratory disease from birth to school age.

2012 - 2015

Swiss National Science Foundation 324730-144280
The prospective Basel-Bern infant lung development birth cohort (BILD): early impact of genetic and environmental factors on lung growth and respiratory morbidity.

2010 - 2015

Co-applicant: IMI - EU Innovative Medicine Initiative U-BIOPRED

Biomarkers of severe asthma

2009 - 2011

Swiss National Science Foundation 32003B-124654

Impact of early envrionmental and genetic determinants on lung development from infancy to preschool age

2008 - 2011

Co-applicant: Swiss National Science Foundation 3200B0-122341

Breastfeeding and the risk of childhood asthma: a population-based study

2008 - 2011

Co-applicant: FP7-EU (EFRAIM Multi-Centre Consortium grant) Responsible for developmental physiology and fieldwork

Scientific or professional organisations

2015 - 2019

Member - Fleischner Society, Society for Thoracic Imaging and Diagnosis, USA

2014 - 2016

President, Division III: Biology and Medicine - Swiss National Foundation

2013  - present

Pediatric Advisory Board - Lancet Respiratory Medicine

2008 - present

Member - Swiss National Science Foundation

2006 - present

Pediatric Editor - European Respiratory Journal

1999 - 2007

ERS Scientific group secretary/chair 7.01 (Pediatric Respiratory Physiology)

1998 - 2001

ERS - ATS Joint Officer (for the Infant lung physiology task force)

Reviewer

SNF, Nature, NEJM, Lancet, PNAS, American Journal Respiratory Critical Care Medicine, Thorax, European Respiratory Journal, Pediatric Pulmonology, Journal of Applied Physiology, Respiration Physiology and Neurobiology, Pediatric Research and others

Research awards

2007

ERS Romain Pauwels Award - Asthma Research in Europe

2005

Swiss Research Prize - Pediatric Pulmonology, for outstanding contribution to the field

2003

Theodor-Kocher Research Prize, University of Bern

2003

Swiss Research Prize - Pediatrics (together with Prof. Wildhaber (Zürich) and Hammer (Baseo) for Research collaboration)

2001

ERS annual Award - Pediatric Respiratory Medicine in Europe

2001

Poster Research Prize - Pulmonolgy (as senior author)

1997

Swiss Research Prize - Pediatrics

Publications

Publications

2019

Usemann J, Suter A, Zannin E, Proietti E, Fouzas S, Schulzke S, Latzin P, Frey U. Variability of Tidal Breathing Parameters in Preterm Infants and Associations with Respiratory Morbidity during Infancy: A Cohort Study. J Pediatr. 2019;205:61-9 e1.

Usemann J, Decrue F, Korten I, Proietti E, Gorlanova O, Vienneau D, Fuchs O, Latzin P, Röösli M, Frey U. Exposure to moderate air pollution and associations with lung function at school-age: A birth cohort study. Environ Int. 2019;126:682-9.

Sinha A, Lutter R, Xu B, Dekker T, Dierdorp B, Sterk PJ, Frey U, Delgado-Eckert ED. Loss of adaptive capacity in asthmatic patients revealed by biomarker fluctuation dynamics after rhinovirus challenge. Elife. 2019;8.

Singh KD, Tancev G, Decrue F, Usemann J, Appenzeller R, Barreiro P, Jaumà G, Macia Santiago M, Vidal de Miguel G, Frey U, Sinues P. Standardization procedures for real-time breath analysis by secondary electrospray ionization high-resolution mass spectrometry. Anal Bioanal Chem. 2019;411(19):4883-98.

Meier-Girard D, Delgado-Eckert E, Schaffner E, Schindler C, Künzli N, Adam M, Pichot V, Kronenberg F, Imboden M, Frey U, Probst-Hensch N. Association of long-term exposure to traffic-related PM10 with heart rate variability and heart rate dynamics in healthy subjects. Environ Int. 2019;125:107-16.

Korten I, Ramsey K, Mika M, Usemann J, Frey U, Hilty M, Hilty M, Latzin P. Nasal Microbiota and Respiratory Tract Infections: The Role of Viral Detection. Am J Respir Crit Care Med. 2019;199(7):919-22.

Korten I, Kieninger E, Yammine S, Cangiano G, Nyilas S, Anagnostopoulou P, Singer F, Kuehni CE, Regamey N, Frey U, Casaulta C, Spycher BD, Latzin P. Respiratory rate in infants with cystic fibrosis throughout the first year of life and association with lung clearance index measured shortly after birth. J Cyst Fibros. 2019;18(1):118-26.

Kochli S, Endes K, Bartenstein T, Usemann J, Schmidt-Trucksass A, Frey U, Zahner L, Hanssen H. Lung function, obesity and physical fitness in young children: The EXAMIN YOUTH study. Respir Med. 2019;159:105813.

Jost K, Datta AN, Frey UP, Suki B, Schulzke SM. Heart rate fluctuation after birth predicts subsequent cardiorespiratory stability in preterm infants. Pediatr Res. 2019;86(3):348-54.

Holguin F, Cardet JC, Chung KF, Diver S, Ferreira DS, Fitzpatrick A, Gaga M, Kellermeyer L, Khurana S, Knight S, McDonald VM, Morgan RL, Ortega VE, Rigau D, Subbarao P, Tonia T, Adcock IM, Bleecker ER, Brightling C, Boulet LP, Cabana M, Castro M, Chanez P, Custovic A, Djukanovic R, Frey U, Frankemolle B, Gibson P, Hamerlijnck D, Jarjour N, Konno S, Shen H, Vitary C, Bush A. Management of Severe Asthma: a European Respiratory Society/American Thoracic Society Guideline. Eur Respir J. 2019.

Frey U, Usemann J. Addressing the complexity of prenatal and postnatal environmental exposures affecting childhood lung function. Lancet Planet Health. 2019;3(2):e51-e2.

Atto B, Eapen MS, Sharma P, Frey U, Ammit AJ, Markos J, Chia C, Larby J, Haug G, Weber HC, Mabeza G, Tristram S, Myers S, Geraghty DP, Flanagan KL, Hansbro PM, Sohal SS. New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways. Clin Sci (Lond). 2019;133(14):1663-703.

2018

Zimmermann K, Cignacco E, Engberg S, Ramelet AS, von der Weid N, Eskola K, et al. Patterns of paediatric end-of-life care: a chart review across different care settings in Switzerland. BMC Pediatr. 2018;18(1):67.

Usemann J, Xu B, Delgado-Eckert E, Korten I, Anagnostopoulou P, Gorlanova O, Kuehni C, Röösli M, Latzin P, Frey U. Dynamics of respiratory symptoms during infancy and associations with wheezing at school age. ERJ Open Res. 2018;4(4).

Pedersen ESL, de Jong CCM, Ardura-Garcia C, Barben J, Casaulta C, Frey U, Jochmann A, Latzin P, Moeller A, Regamey N, Singer F, Spycher B, Sutter O, Goutaki M, Kuehni CE. The Swiss Paediatric Airway Cohort (SPAC). ERJ Open Res. 2018;4(4).

Neumann RP, Hilty M, Xu B, Usemann J, Korten I, Mika M, Müller L, Latzin P, Frey U. Nasal microbiota and symptom persistence in acute respiratory tract infections in infants. ERJ Open Res. 2018;4(4).

Lura MP, Gorlanova O, Muller L, Proietti E, Vienneau D, Reppucci D, Pavlovic R, Dahinden C, Röösli M, Latzin P, Frey U. Response of cord blood cells to environmental, hereditary and perinatal factors: A prospective birth cohort study. PLoS One. 2018;13(7):e0200236.

Lupatsch JE, Kreis C, Korten I, Latzin P, Frey U, Kuehni CE, Spycher BD. Neighbourhood child population density as a proxy measure for exposure to respiratory infections in the first year of life: A validation study. PLoS One. 2018;13(9):e0203743.

Korten I, Liechti M, Singer F, Hafen G, Rochat I, Anagnostopoulou P, Müller-Suter D, Usemann J, Moeller A, Frey U, Latzin P, Casaulta C; SCILD and BILD study group. Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls. J Cyst Fibros. 2018;17(1):105-8.

Korten I, Kieninger E, Klenja S, Mack I, Schlapfer N, Barbani MT, N, Kuehni CE, Hilty M, Frey U, Gorgievski M, Casaulta C, Latzin P. Respiratory viruses in healthy infants and infants with cystic fibrosis: a prospective cohort study. Thorax. 2018;73(1):13-20.

Gorlanova O, Illi S, Toncheva AA, Usemann J, Latzin P, Kabesch M, et al. Protective effects of breastfeeding on respiratory symptoms in infants with 17q21 asthma risk variants. Allergy. 2018;73(12):2388-92.

Delgado-Eckert E, Fuchs O, Kumar N, Pekkanen J, Dalphin JC, Riedler J, et al. Functional phenotypes determined by fluctuation-based clustering of lung function measurements in healthy and asthmatic cohort participants. Thorax. 2018;73(2):107-15.

Cantuaria ML, Usemann J, Proietti E, Blanes-Vidal V, Dick B, Fluck CE, Rüedi S, Héritier H, Wunderli JM, Latzin P, Frey U, Röösli M, Vienneau D; BILD study group. Glucocorticoid metabolites in newborns: A marker for traffic noise related stress? Environ Int. 2018;117:319-26.

Pavord ID, Beasley R, Agusti A, Anderson GP, Bel E, Brusselle G, Cullinan P, Custovic A, Ducharme FM, Fahy JV, Frey U, Gibson P, Heaney LG, Holt PG, Humbert M, Lloyd CM, Marks G, Martinez FD, Sly PD, von Mutius E, Wenzel S, Zar HJ, Bush A. After asthma: redefining airways diseases. Lancet. 2018;391(10118):350-400.

Singh KD, Del Miguel GV, Gaugg MT, Ibanez AJ, Zenobi R, Kohler M, Frey U, Sinues PM. Translating secondary electrospray ionization-high-resolution mass spectrometry to the clinical environment. J Breath Res. 2018;12(2):027113.

2017

Usemann J, Demann D, Anagnostopoulou P, Korten I, Gorlanova O, Schulzke S, Frey U, Latzin P. Interrupter technique in infancy: Higher airway resistance and lower short-term variability in preterm versus term infants. Pediatr Pulmonol. 2017;52(10):1355-62.

Suki B, Frey U. A time-varying biased random walk approach to human growth. Sci Rep. 2017;7(1):7805.

Mika M, Maurer J, Korten I, Allemann A, Aebi S, Brugger SD, Qi W, Frey U, Latzin P, Hilty M. Influence of the pneumococcal conjugate vaccines on the temporal variation of pneumococcal carriage and the nasal microbiota in healthy infants: a longitudinal analysis of a case-control study. Microbiome. 2017;5(1):85.

Kieninger E, Yammine S, Korten I, Anagnostopoulou P, Singer F, Frey U, Mornand A, Zanolari M, Rochat I, Trachsel D, Mueller-Suter D, Moeller A, Casaulta C, Latzin P; SCILD study group; BILD study group. Elevated lung clearance index in infants with cystic fibrosis shortly after birth. Eur Respir J. 2017;50(5).

Jost K, Scherer S, De Angelis C, Buchler M, Datta AN, Cattin PC, Frey U, Suki B, Schulzke SM. Surface electromyography for analysis of heart rate variability in preterm infants. Physiol Meas. 2017;39(1):015004. 

Jost K, Pramana I, Delgado-Eckert E, Kumar N, Datta AN, Frey U, Schulzke SM. Dynamics and complexity of body temperature in preterm infants nursed in incubators. PLoS One. 2017;12(4):e0176670.

Jost K, Egger B, Kieninger E, Singer F, Frey U, Latzin P. Changes in minute ventilation after exposure to 4% sulfur hexafluoride (SF6 ) in infants. Pediatr Pulmonol. 2017;52(2):151-3.

Jochmann A, Artusio L, Jamalzadeh A, Nagakumar P, Delgado-Eckert E, Saglani S, Bush A, Frey U, Fleming L. Electronic monitoring of adherence to inhaled corticosteroids: an essential tool in identifying severe asthma in children. Eur Respir J. 2017;50(6).

Fuchs O, Gorlanova O, Latzin P, Schmidt A, Schieck M, Toncheva AA, Michel S, Gaertner VD, Kabesch M, Frey U. 6q12 and 11p14 variants are associated with postnatal exhaled nitric oxide levels and respiratory symptoms. J Allergy Clin Immunol. 2017;140(4):1015-23.

Fouzas S, Theodorakopoulos I, Delgado-Eckert E, Latzin P, Frey U. Breath-to-breath variability of exhaled CO2 as a marker of lung dysmaturity in infancy. J Appl Physiol (1985). 2017;123(6):1563-70.

Nyilas S, Bauman G, Sommer G, Stranzinger E, Pusterla O, Frey U, Korten I, Singer F, Casaulta C, Bieri O, Latzin P. Novel magnetic resonance technique for functional imaging of cystic fibrosis lung disease. Eur Respir J. 2017 Dec 7;50(6).

Frey U, Bielicki JA. Fluctuation Metrics as Novel Endpoints for Clinical Trials in Asthma. Am J Respir Crit Care Med. 2017;195(8):967-8.

Thamrin C, Frey U, Kaminsky DA, Reddel HK, Seely AJE, Suki B, et al. Reply: Complexity Analysis of Respiratory Dynamics. Am J Respir Crit Care Med. 2017;196(2):248-9.

2016

Yammine S, Schmidt A, Sutter O, Fouzas S, Singer F, Frey U, Latzin P. Functional evidence for continued alveolarisation in former preterms at school age? Eur Respir J. 2016;47(1):147-55.

Usemann J, Fuchs O, Anagnostopoulou P, Korten I, Gorlanova O, Roosli M, Latzin P, Frey U. Predictive value of exhaled nitric oxide in healthy infants for asthma at school age. Eur Respir J. 2016;48(3):925-8.

Usemann J, Frey U, Mack I, Schmidt A, Gorlanova O, Roosli M, Hartl D, Latzin P. CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development. BMC Pulm Med. 2016;16(1):81.

Proietti E, Delgado-Eckert E, Vienneau D, Stern G, Tsai MY, Latzin P, et al. Air pollution modelling for birth cohorts: a time-space regression model. Environ Health. 2016;15(1):61.

Nyilas S, Singer F, Kumar N, Yammine S, Meier-Girard D, Koerner-Rettberg C, Casaulta C, Frey U, Latzin P. Physiological phenotyping of pediatric chronic obstructive airway diseases. J Appl Physiol (1985). 2016;121(1):324-32.

Neumann RP, Pillow JJ, Thamrin C, Frey U, Schulzke SM. Influence of respiratory dead space on lung clearance index in preterm infants. Respir Physiol Neurobiol. 2016;223:43-8.

Mustonen K, Karvonen AM, Kirjavainen P, Roponen M, Schaub B, Hyvarinen A, Frey U, Renz H, Pfefferle PI, Genuneit J, Vaarala O, Pekkanen J. Moisture damage in home associates with systemic inflammation in children. Indoor Air. 2016;26(3):439-47.

Mika M, Korten I, Qi W, Regamey N, Frey U, Casaulta C, Latzin P, Hilty M; SCILD study group. The nasal microbiota in infants with cystic fibrosis in the first year of life: a prospective cohort study. Lancet Respir Med. 2016;4(8):627-35.

Mack I, Kieninger E, Cangiano G, Tapparel C, Kuehni C, Spycher B, Kaiser L, Frey U, Regamey N, Latzin P. Rhinovirus Infections and Associated Respiratory Morbidity in Infants: A Prospective Cohort Study. Pediatr Infect Dis J. 2016;35(10):1069-74.

Korten I, Mika M, Klenja S, Kieninger E, Mack I, Barbani MT, Gorgievski M, Frey U, Hilty M, Latzin P. Interactions of Respiratory Viruses and the Nasal Microbiota during the First Year of Life in Healthy Infants. mSphere. 2016;1(6).

Jost K, Lenherr N, Singer F, Schulzke SM, Frey U, Latzin P, Yammine S. Changes in breathing pattern upon 100% oxygen in children at early school age. Respir Physiol Neurobiol. 2016;228:9-15.

Gorlanova O, Thalmann S, Proietti E, Stern G, Latzin P, Kuhni C, Röösli M, Frey U. Effects of Breastfeeding on Respiratory Symptoms in Infancy. J Pediatr. 2016;174:111-7 e5.

Egger B, Jost K, Anagnostopoulou P, Yammine S, Singer F, Casaulta C, Frey U, Latzin P. Lung clearance index and moment ratios at different cut-off values in infant multiple-breath washout measurements. Pediatr Pulmonol. 2016;51(12):1373-81.

den Dekker HT, Sonnenschein-van der Voort AMM, de Jongste JC, Anessi-Maesano I, Arshad SH, Barros H, et al. Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children. J Allergy Clin Immunol. 2016;137(4):1026-35.

Cremer M, Jost K, Gensmer A, Pramana I, Delgado-Eckert E, Frey U, Schulzke SM, Datta A. Immediate effects of phototherapy on sleep in very preterm neonates: an observational study. J Sleep Res. 2016;25(5):517-23.

Anagnostopoulou P, Egger B, Lura M, Usemann J, Schmidt A, Gorlanova O, Korten I, Roos M, Frey U, Latzin P. Multiple breath washout analysis in infants: quality assessment and recommendations for improvement. Physiol Meas. 2016;37(3):L1-L15.

Bush A, Frey U. Safety of Long-Acting Beta-Agonists in Children with Asthma. N Engl J Med. 2016;375(9):889-91.

Thamrin C, Frey U, Kaminsky DA, Reddel HK, Seely AJ, Suki B, Sterk PJ. Systems Biology and Clinical Practice in Respiratory Medicine. The Twain Shall Meet. Am J Respir Crit Care Med. 2016;194(9):1053-61.

2015

Shaw DE, Sousa AR, Fowler SJ, Fleming LJ, Roberts G, Corfield J, et al. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. Eur Respir J. 2015;46(5):1308-21.

Schmidt A, Yammine S, Proietti E, Frey U, Latzin P, Riedel T, Singer F. Validation of multiple-breath washout equipment for infants and young children. Pediatr Pulmonol. 2015;50(6):607-14.

Petrus NC, Thamrin C, Fuchs O, Frey U. Accuracy of tidal breathing measurement of FloRight compared to an ultrasonic flowmeter in infants. Pediatr Pulmonol. 2015;50(4):380-8.

Muller L, Mack I, Tapparel C, Kaiser L, Alves MP, Kieninger E, Frey U, Regamey N, Latzin P. Human Rhinovirus Types and Association with Respiratory Symptoms During the First Year of Life. Pediatr Infect Dis J. 2015;34(8):907-9.

Mika M, Mack I, Korten I, Qi W, Aebi S, Frey U, Frey U, Regamey N, Latzin P. Dynamics of the nasal microbiota in infancy: a prospective cohort study. J Allergy Clin Immunol. 2015;135(4):905-12 e11.

Jost K, Latzin P, Fouzas S, Proietti E, Delgado-Eckert EW, Frey U, Schulzke SM. Sigh-induced changes of breathing pattern in preterm infants. Physiol Rep. 2015;3(11).

Girard D, Delgado-Eckert E, Schaffner E, Hacki C, Adam M, Stern GL, Kumar N, Felber Dietrich D, Turk A, Pons M, Künzli N, Gaspoz JM, Rochat T, Schindler C, Probst-Hensch N, Frey U. Long-term smoking cessation and heart rate dynamics in an aging healthy cohort: Is it possible to fully recover? Environ Res. 2015;143(Pt A):39-48.

Fleming L, Murray C, Bansal AT, Hashimoto S, Bisgaard H, Bush A, et al. The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts. Eur Respir J. 2015;46(5):1322-33.

Bartolak-Suki E, Imsirovic J, Parameswaran H, Wellman TJ, Martinez N, Allen PG, Frey U, Suki B. Fluctuation-driven mechanotransduction regulates mitochondrial-network structure and function. Nat Mater. 2015;14(10):1049-57.

Frey U, Latzin P, Usemann J, Maccora J, Zumsteg U, Kriemler S. Asthma and obesity in children: current evidence and potential systems biology approaches. Allergy. 2015;70(1):26-40.

2014

Sonnenschein-van der Voort AM, Arends LR, de Jongste JC, Annesi-Maesano I, Arshad SH, Barros H, et al. Preterm birth, infant weight gain, and childhood asthma risk: a meta-analysis of 147,000 European children. J Allergy Clin Immunol. 2014;133(5):1317-29.

Singer F, Yammine S, Schmidt A, Proietti E, Kieninger E, Barben J, Casaulta C, Regamey N, Gustafsson P, Frey U, Latzin P. Ventilatory response to nitrogen multiple-breath washout in infants. Pediatr Pulmonol. 2014;49(4):342-7.

Singer F, Abbas C, Yammine S, Casaulta C, Frey U, Latzin P. Abnormal small airways function in children with mild asthma. Chest. 2014;145(3):492-9.

Proietti E, Riedel T, Fuchs O, Pramana I, Singer F, Schmidt A, Kuehni C, Latzin P, Frey U. Can infant lung function predict respiratory morbidity during the first year of life in preterm infants? Eur Respir J. 2014;43(6):1642-51.

Fouzas S, Hacki C, Latzin P, Proietti E, Schulzke S, Frey U, Delgado-Eckert E. Volumetric capnography in infants with bronchopulmonary dysplasia. J Pediatr. 2014;164(2):283-8 e1-3.

Mika M, Korten I, Qi W, Regamey N, Frey U, Casaulta C, Latzin P, Hilty M; SCILD study group. The nasal microbiota in infants with cystic fibrosis in the first year of life: a prospective cohort study. Lancet Respir Med. 2016 Aug;4(8):627-635.

Schmidt A, Yammine S, Proietti E, Frey U, Latzin P, Riedel T, Singer F. Validation of multiple-breath washout equipment for infants and young children. Pediatr Pulmonol. 2015 Jun;50(6):607-14.

Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, Bateman ED, Bel EH, Bleecker ER, Boulet LP, Brightling C, Chanez P, Dahlen SE, Djukanovic R, Frey U, Gaga M, Gibson P, Hamid Q, Jajour NN, Mauad T, Sorkness RL, Teague WG.

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014 Feb;43(2):343-73

Schulzke SM, Frey U. Lung clearance index: should we really go back to nitrogen washout? Eur Respir J. 2014;43(2):656-7.

Wenger P, Frey U, Nadal D. Research dedicated to children: SwissPedNet with its international links overcomes key barriers to proper research in paediatrics. Swiss Med Wkly. 2014;144:w14006.

2013

Waldmeier S, Grunt S, Delgado-Eckert E, Latzin P, Steinlin M, Fuhrer K, Frey U. Correlation properties of spontaneous motor activity in healthy infants: a new computer-assisted method to evaluate neurological maturation. Exp Brain Res. 2013;227(4):433-46.

Stern G, Latzin P, Roosli M, Fuchs O, Proietti E, Kuehni C, Frey U. A prospective study of the impact of air pollution on respiratory symptoms and infections in infants. Am J Respir Crit Care Med. 2013;187(12):1341-8.

Singer F, Stern G, Thamrin C, Abbas C, Casaulta C, Frey U, Latzin P. A new double-tracer gas single-breath washout to assess early cystic fibrosis lung disease. Eur Respir J. 2013;41(2):339-45.

Singer F, Kieninger E, Abbas C, Yammine S, Fuchs O, Proietti E, Regamey N, Casaulta C, Frey U, Latzin P. Practicability of nitrogen multiple-breath washout measurements in a pediatric cystic fibrosis outpatient setting. Pediatr Pulmonol. 2013;48(8):739-46.

Kieninger E, Fuchs O, Latzin P, Frey U, Regamey N. Rhinovirus infections in infancy and early childhood. Eur Respir J. 2013;41(2):443-52.

Frey U, Barben J, Hammer J. [Obstructive air way disease in infants and children]. Ther Umsch. 2013;70(11):669-79.

Proietti E, Roosli M, Frey U, Latzin P. Air pollution during pregnancy and neonatal outcome: a review. J Aerosol Med Pulm Drug Deliv. 2013;26(1):9-23.

2012

Fuchs O, Latzin P, Singer F, Petrus N, Proietti E, Kieninger E, Casaulta C, Frey U. Comparison of online single-breath vs. online multiple-breath exhaled nitric oxide in school-age children. Pediatr Res. 2012;71(5):605-11.

Fuchs O, Latzin P, Kuehni CE, Frey U. Cohort profile: the Bern infant lung development cohort. Int J Epidemiol. 2012;41(2):366-76.

Fuchs O, Genuneit J, Latzin P, Buchele G, Horak E, Loss G, Sozanska B, Weber J, Boznanski A, Heederik D, Braun-Fahrländer C, Frey U, von Mutius E. Farming environments and childhood atopy, wheeze, lung function, and exhaled nitric oxide. J Allergy Clin Immunol. 2012;130(2):382-8 e6.

Dogaru CM, Strippoli MP, Spycher BD, Frey U, Beardsmore CS, Silverman M, Kuhni CE. Breastfeeding and lung function at school age: does maternal asthma modify the effect? Am J Respir Crit Care Med. 2012;185(8):874-80.

Van der Valk RJ, Baraldi E, Stern G, Frey U, de Jongste JC. Daily exhaled nitric oxide measurements and asthma exacerbations in children. Allergy. 2012 Feb;67(2):265-71.

2011

Thamrin C, Zindel J, Nydegger R, Reddel HK, Chanez P, Wenzel SE, FitzPatrick S, Watt RA, Suki B, Frey U. Predicting future risk of asthma exacerbations using individual conditional probabilities. J Allergy Clin Immunol. 2011;127(6):1494-502 e3.

Thamrin C, Nydegger R, Stern G, Chanez P, Wenzel SE, Watt RA, FitzPatrick S, Taylor DR, Frey U. Associations between fluctuations in lung function and asthma control in two populations with differing asthma severity. Thorax. 2011;66(12):1036-42.

Stern G, de Jongste J, van der Valk R, Baraldi E, Carraro S, Thamrin C, Frey U. Fluctuation phenotyping based on daily fraction of exhaled nitric oxide values in asthmatic children. J Allergy Clin Immunol. 2011;128(2):293-300.

Singer F, Stern G, Thamrin C, Fuchs O, Riedel T, Gustafsson P, Frey U, Latzin P. Tidal volume single breath washout of two tracer gases--a practical and promising lung function test. PLoS One. 2011;6(3):e17588.

Pramana IA, Latzin P, Schlapbach LJ, Hafen G, Kuehni CE, Nelle M, Riedel T, Frey U. Respiratory symptoms in preterm infants: burden of disease in the first year of life. Eur J Med Res. 2011;16(5):223-30.

Leonardi NA, Spycher BD, Strippoli MP, Frey U, Silverman M, Kuehni CE. Validation of the Asthma Predictive Index and comparison with simpler clinical prediction rules. J Allergy Clin Immunol. 2011;127(6):1466-72 e6.

Latzin P, Frey U, Armann J, Kieninger E, Fuchs O, Roosli M, Schaub B. Exposure to moderate air pollution during late pregnancy and cord blood cytokine secretion in healthy neonates. PLoS One. 2011;6(8):e23130.

Kieninger E, Singer F, Fuchs O, Abbas C, Frey U, Regamey N, Casaulta C, Latzin P. Long-term course of lung clearance index between infancy and school-age in cystic fibrosis subjects. J Cyst Fibros. 2011;10(6):487-90.

Fuchs O, Latzin P, Thamrin C, Stern G, Frischknecht P, Singer F, Kieninger E, Proietti E, Riedel T, Frey U. Normative data for lung function and exhaled nitric oxide in unsedated healthy infants. Eur Respir J. 2011;37(5):1208-16.

Frey U, Maksym G, Suki B. Temporal complexity in clinical manifestations of lung disease. J Appl Physiol (1985). 2011;110(6):1723-31.

2010

Thamrin C, Taylor DR, Jones SL, Suki B, Frey U. Variability of lung function predicts loss of asthma control following withdrawal of inhaled corticosteroid treatment. Thorax. 2010;65(5):403-8.

Ochs K, Hoksch B, Frey U, Schmid RA. Inflammatory myofibroblastic tumour of the lung in a five-year-old girl. Interact Cardiovasc Thorac Surg. 2010;10(5):805-6.

Hutten GJ, van Eykern LA, Latzin P, Thamrin C, van Aalderen WM, Frey U. Respiratory muscle activity related to flow and lung volume in preterm infants compared with term infants. Pediatr Res. 2010;68(4):339-43.

Thamrin C, Stern G, Frey U. Fractals for physicians. Paediatr Respir Rev. 2010;11(2):123-31.

2009

Thamrin C, Stern G, Strippoli MP, Kuehni CE, Suki B, Taylor DR, et al. Fluctuation analysis of lung function as a predictor of long-term response to beta2-agonists. Eur Respir J. 2009;33(3):486-93.

Stern G, Beel J, Suki B, Silverman M, Westaway J, Cernelc M, et al. Long-range correlations in rectal temperature fluctuations of healthy infants during maturation. PLoS One. 2009;4(7):e6431.

Schlapbach LJ, Latzin P, Regamey N, Kuehni CE, Zwahlen M, Casaulta C, et al. Mannose-binding lectin cord blood levels and respiratory symptoms during infancy: a prospective birth cohort study. Pediatr Allergy Immunol. 2009;20(3):219-26.

Riedel T, Kyburz M, Latzin P, Thamrin C, Frey U. Regional and overall ventilation inhomogeneities in preterm and term-born infants. Intensive Care Med. 2009;35(1):144-51.

Latzin P, Roth S, Thamrin C, Hutten GJ, Pramana I, Kuehni CE, et al. Lung volume, breathing pattern and ventilation inhomogeneity in preterm and term infants. PLoS One. 2009;4(2):e4635.

Latzin P, Roosli M, Huss A, Kuehni CE, Frey U. Air pollution during pregnancy and lung function in newborns: a birth cohort study. Eur Respir J. 2009;33(3):594-603.

Kraemer R, Latzin P, Pramana I, Ballinari P, Gallati S, Frey U. Long-term gas exchange characteristics as markers of deterioration in patients with cystic fibrosis. Respir Res. 2009;10:106.

Frey U, Egert U, Heer F, Hafizovic S, Hierlemann A. Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices. Biosens Bioelectron. 2009;24(7):2191-8.

2008

Waffler-Kammermann N, Lacorcia RS, Wettstein M, Radlinger L, Frey U. A new standardized treadmill walking test requiring low motor skills in children aged 4-10 years. Pediatr Pulmonol. 2008;43(2):187-95.

Thamrin C, Frey U. Effect of bacterial filter on measurement of interrupter resistance in preschool and school-aged children. Pediatr Pulmonol. 2008;43(8):781-7.

Regamey N, Kaiser L, Roiha HL, Deffernez C, Kuehni CE, Latzin P, et al. Viral etiology of acute respiratory infections with cough in infancy: a community-based birth cohort study. Pediatr Infect Dis J. 2008;27(2):100-5.

Minocchieri S, Burren JM, Bachmann MA, Stern G, Wildhaber J, Buob S, et al. Development of the premature infant nose throat-model (PrINT-Model): an upper airway replica of a premature neonate for the study of aerosol delivery. Pediatr Res. 2008;64(2):141-6.

Latzin P, Hartl D, Regamey N, Frey U, Schoeni MH, Casaulta C. Comparison of serum markers for allergic bronchopulmonary aspergillosis in cystic fibrosis. Eur Respir J. 2008;31(1):36-42.

Hutten GJ, van Eykern LA, Latzin P, Kyburz M, van Aalderen WM, Frey U. Relative impact of respiratory muscle activity on tidal flow and end expiratory volume in healthy neonates. Pediatr Pulmonol. 2008;43(9):882-91.

Frey U, Suki B. Complexity of chronic asthma and chronic obstructive pulmonary disease: implications for risk assessment, and disease progression and control. Lancet. 2008;372(9643):1088-99.

2007

Thamrin C, Latzin P, Sauteur L, Riedel T, Hall GL, Frey U. Deadspace estimation from CO2 versus molar mass measurements in infants. Pediatr Pulmonol. 2007;42(10):920-7.

Roiha HL, Kuehni CE, Zanolari M, Zwahlen M, Baldwin DN, Casaulta C, Nelle M, Frey U. Alterations of exhaled nitric oxide in pre-term infants with chronic lung disease. Eur Respir J. 2007;29(2):251-8.

Regamey N, Frey U, Deffernez C, Latzin P, Kaiser L, Swiss Paediatric Respiratory Research G. Isolation of human bocavirus from Swiss infants with respiratory infections. Pediatr Infect Dis J. 2007;26(2):177-9.

Pachlopnik Schmid JM, Kuehni CE, Strippoli MP, Roiha HL, Pavlovic R, Latzin P, Gallati S, Kraemer R, Dahinden C, Frey U. Maternal tobacco smoking and decreased leukocytes, including dendritic cells, in neonates. Pediatr Res. 2007;61(4):462-6.

Latzin P, Sauteur L, Thamrin C, Schibler A, Baldwin D, Hutten GJ, Kyburz M, Kraemer R, Riedel T, Frey U. Optimized temperature and deadspace correction improve analysis of multiple breath washout measurements by ultrasonic flowmeter in infants. Pediatr Pulmonol. 2007;42(10):888-97.

Latzin P, Frey U, Roiha HL, Baldwin DN, Regamey N, Strippoli MP, Zwahlen M, Kuehni CE. Prospectively assessed incidence, severity, and determinants of respiratory symptoms in the first year of life. Pediatr Pulmonol. 2007;42(1):41-50.

Frey U. Predicting asthma control and exacerbations: chronic asthma as a complex dynamic model. Curr Opin Allergy Clin Immunol. 2007;7(3):223-30.

Stern G, Latzin P, Thamrin C, Frey U. How can we measure the impact of pollutants on respiratory function in very young children? Methodological aspects. Paediatr Respir Rev. 2007;8(4):299-304.

2006

Pfammatter JP, Casaulta C, Pavlovic M, Berdat PA, Frey U, Carrel T. Important excess morbidity due to upper airway anomalies in the perioperative course in infant cardiac surgery. Ann Thorac Surg. 2006;81(3):1008-12.

Latzin P, Kuehni CE, Baldwin DN, Roiha HL, Casaulta C, Frey U. Elevated exhaled nitric oxide in newborns of atopic mothers precedes respiratory symptoms. Am J Respir Crit Care Med. 2006;174(12):1292-8.

Kraemer R, Baldwin DN, Ammann RA, Frey U, Gallati S. Progression of pulmonary hyperinflation and trapped gas associated with genetic and environmental factors in children with cystic fibrosis. Respir Res. 2006;7:138.

Kondo T, Minocchieri S, Baldwin DN, Nelle M, Frey U. Noninvasive monitoring of chest wall movement in infants using laser. Pediatr Pulmonol. 2006;41(10):985-92.

2005

Kaiser L, Regamey N, Roiha H, Deffernez C, Frey U. Human coronavirus NL63 associated with lower respiratory tract symptoms in early life. Pediatr Infect Dis J. 2005;24(11):1015-7.

Frey U, Brodbeck T, Majumdar A, Taylor DR, Town GI, Silverman M, Suki B. Risk of severe asthma episodes predicted from fluctuation analysis of airway function. Nature. 2005;438(7068):667-70.

Frey U. Forced oscillation technique in infants and young children. Paediatr Respir Rev. 2005;6(4):246-54.

2004

Straub DA, Ehmann R, Hall GL, Moeller A, Hamacher J, Frey U, Sennhauser F, Wildhaber JH. Correlation of nitrites in breath condensates and lung function in asthmatic children. Pediatr Allergy Immunol. 2004;15(1):20-5.

Frey U, Kuehni C, Roiha H, Cernelc M, Reinmann B, Wildhaber JH, Hall GL. Maternal atopic disease modifies effects of prenatal risk factors on exhaled nitric oxide in infants. Am J Respir Crit Care Med. 2004;170(3):260-5.

Frey U, Hislop A, Silverman M. Branching properties of the pulmonary arterial tree during pre- and postnatal development. Respir Physiol Neurobiol. 2004;139(2):179-89.

Baldwin DN, Suki B, Pillow JJ, Roiha HL, Minocchieri S, Frey U. Effect of sighs on breathing memory and dynamics in healthy infants. J Appl Physiol (1985). 2004;97(5):1830-9.

2003

Duppenthaler A, Gorgievski-Hrisoho M, Frey U, Aebi C. Two-year periodicity of respiratory syncytial virus epidemics in Switzerland. Infection. 2003;31(2):75-80.

2002

Schibler A, Hall GL, Businger F, Reinmann B, Wildhaber JH, Cernelc M, Frey U. Measurement of lung volume and ventilation distribution with an ultrasonic flow meter in healthy infants. Eur Respir J. 2002;20(4):912-8.

Kuehni CE, Frey U. Age-related differences in perceived asthma control in childhood: guidelines and reality. Eur Respir J. 2002;20(4):880-9.

Hall GL, Reinmann B, Wildhaber JH, Frey U. Tidal exhaled nitric oxide in healthy, unsedated newborn infants with prenatal tobacco exposure. J Appl Physiol (1985). 2002;92(1):59-66.

Formanek W, Inci D, Lauener RP, Wildhaber JH, Frey U, Hall GL. Elevated nitrite in breath condensates of children with respiratory disease. Eur Respir J. 2002;19(3):487-91.

Cernelc M, Suki B, Reinmann B, Hall GL, Frey U. Correlation properties of tidal volume and end-tidal O2 and CO2 concentrations in healthy infants. J Appl Physiol (1985). 2002;92(5):1817-27.

Aebischer CC, Frey U, Schoni MH. Hypersensitivity pneumonitis in a five-year-old boy: an unusual antigen source. Pediatr Pulmonol. 2002;33(1):77-8.

Schibler A, Frey U. Role of lung function testing in the management of mechanically ventilated infants. Arch Dis Child Fetal Neonatal Ed. 2002;87(1):F7-F10.

2001

Schibler A, Frey U, Kraemer R. An isoflow-volume technique for assessing airway dynamics in children and adults. Respiration. 2001;68(2):192-9.

Reinmann B, Stocks J, Frey U. Assessment of an infant whole-body plethysmograph using an infant lung function model. Eur Respir J. 2001;17(4):765-72.

Frey U, Silverman M, Suki B. Analysis of the harmonic content of the tidal flow waveforms in infants. J Appl Physiol (1985). 2001;91(4):1687-93.

Frey U, Reinmann B, Stocks J. The infant lung function model: a mechanical analogue to test infant lung function equipment. Eur Respir J. 2001;17(4):755-64.

Frey U. Clinical applications of infant lung function testing: does it contribute to clinical decision making? Paediatr Respir Rev. 2001;2(2):126-30.

2000

Schibler A, Schneider M, Frey U, Kraemer R. Moment ratio analysis of multiple breath nitrogen washout in infants with lung disease. Eur Respir J. 2000;15(6):1094-101.

Frey U, Stocks J, Sly P, Bates J. Specification for signal processing and data handling used for infant pulmonary function testing. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/American Thoracic Society. Eur Respir J. 2000;16(5):1016-22.

Frey U, Stocks J, Coates A, Sly P, Bates J. Specifications for equipment used for infant pulmonary function testing. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/ American Thoracic Society. Eur Respir J. 2000;16(4):731-40.

1991-1999

Rohrbach M, Frey U, Kraemer R, Liechti-Gallati S. A variant in the gene for GM-CSF, I117T, is associated with atopic asthma in a Swiss population of asthmatic children. J Allergy Clin Immunol. 1999;104(1):247-8.

Frey U, Kraemer R. Oscillatory pressure transients after flow interruption during bronchial challenge test in children. Eur Respir J. 1997;10(1):75-81 

Frey U, Schibler A, Kraemer R. Pressure oscillations after flow interruption in relation to lung mechanics. Respir Physiol. 1995;102(2-3):225-37.

Frey U, Kraemer R. Interrelationship between postocclusional oscillatory pressure transients and standard lung function in healthy and asthmatic children. Pediatr Pulmonol. 1995;19(6):379-88.

Sommer CW, Frey U, Schonli MH, Kraemer R. Specific approach on dose-response curves to inhaled carbachol assessed by the interruption technique in children. Pediatr Res. 1993;34(4):478-84.

Frey U, Schibler A, Kraemer R. The interrupter technique--a renaissance of a non-invasive approach for lung function testing in infants and children. Agents Actions Suppl. 1993;40:64-72.

Kraemer R, Frey U, Sommer CW, Russi E. Short-term effect of albuterol, delivered via a new auxiliary device, in wheezy infants. Am Rev Respir Dis. 1991;144(2):347-51.

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Prof. Urs Frey, MD, PhD

Medical Director UKBB, Chief Physician Pediatrics, Member of the Executive Board, Research Group Leader

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