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The focus of the research of the Laboratory of Pediatric Immunology is to delineate the molecular and cellular pathways that govern regular thymus organogenesis and function. Specifically, the lab is interested in:
Using gene targeting we have generated unique tools that allow compartment-specific, experimental gain- and loss-of-function models in mice to interrogate aspects of thymus development and function at the cellular and molecular level.
A special interest of our research is focused on studying the role of specific transcription factors such as Foxn1 and understanding the epigenetic «code» that determine the regulatory principles operative in TEC biology. Taking advantage of different molecular methods integrating imaging, flow cytometry, spatial transcriptomics and epigenomics, we analyze specific TEC subpopulations at distinct developmental stages in health and disease. Numerical, structural and functional changes in TEC are related to to the ability to maintain regular immunological functions, in particular the establishment and maintenance of immunological tolerance.
The research group has a «Sister laboratory» at the Weatherall Institute for Molecular Medicine, University of Oxford, United Kingdom
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145 (Poison and Information Centre)
University Children's Hospital of both
Basel, Spitalstrasse 33
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Phone +41 61 704 12 12
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The Medgate Kids Line provides quick and uncomplicated medical advice if your child is unwell. The medical team of our partner Medgate is available to you by telephone around the clock.
For emergencies abroad: Call the emergency number of your health insurance company. You will find this number on your health insurance card.
More information: On the Page of the emergency ward you will find everything you need to know about behaviour in emergencies, typical childhood illnesses and waiting times.
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