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0900 712 712
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0900 712 713
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University Children’s Hospital Basel
T +41 61 704 12 12
F +41 61 704 12 13
Breath is an underexploited body
fluid, which contains valuable biochemical information at the metabolic level.
Our mission is to uncap the potential that breath analysis holds as a non-invasive
method to assist in clinical decision making. We are a multidisciplinary team
of scientists embedded at the University of Basel Children’s Hospital (UKBB)
since June 2017. Being physically rooted within a clinical context provides us
with the unique advantage of interacting with clinicians and having direct
access to patients.
Secondary Electrospray Ionization-High Resolution Mass Spectrometry (SESI-HRMS) breath analysis platform at UKBB. This technique allows us to capture rich metabolic breath-prints of patients in a totally non-invasive and real-time fashion.
Pneumonia is the leading infectious cause of death worldwide, mainly among children. For example, pneumonia accounts for 15% of all deaths in children less than 5 years of age (an estimated 935,000 children each year). Globally, pneumonia affects approximately 450 million people, and results in about 4 million deaths, per year. Hence, it exacts an enormous cost in economic and human terms. Early diagnosis is crucial for treatment success and improvement of outcome. However, the high morbidity and mortality of pneumonia is partly due to the lack of efficient diagnostics.
Our ultimate objective will be diagnosing bacterial pneumonia using a non-invasive breath test, that will deliver a positive/negative response and will identify a subset of causing pathogens in ~15 min. The figure describes the clinical problem and the proposed solution.
This work is part of the Zurich Exhalomics project under the umbrella of "University Medicine Zurich/Hochschulmedizin Zürich"
Diagnosis of bacterial pneumonia (Funded by the Swiss National Science Foundation)
Master and Semester Projects
We offer the opportunity to make master and semester projects in the areas of breath analysis with Secondary Electrospray Ionization-Mass Spectrometry (SESI-MS)
If you are interested, please send applications with CV and
grade transcripts to Prof. Dr. Pablo M-L Sinues.
Only available in German
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© UKBB, 2019