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0900 712 712

(3.23 CHF / min. from the Swiss landline, possibly additionally 8 Rp. / min. by network operator)

 
 

0900 712 713

(3.12 CHF / min. for calls from prepaid cell phones, possibly additionally 8 Rp. / min. by network operator)


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UKBB

University Children’s Hospital Basel
Spitalstrasse 33
4056 Basel
Switzerland

T +41 61 704 12 12
F +41 61 704 12 13

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For making an appointment or the postponement of an appointment, please contact polyclinic head office +41 61 704 12 20

 
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Molecular Therapeutic Strategies in Pediatric Surgery

Pediatric surgical research is inevitably linked to solid tumors and cancers of childhood. Pediatric cancers are rare and fortunately the outcome compared to adults is good. Surgical, oncological and interdisciplinary approaches have further improved the outcome in the past. Nevertheless there is a need for identifying underlying mechanisms of tumor development and tumor cell migration that can lead to the development of novel therapeutic approaches.

The research of our group has focused on mechanisms of tumor progression and migration and their inhibitions in solid tumors, and, in recent years, particularly on hypoxia-dependent factors that enhance proliferation and metastases in neuroblastoma. Neuroblastoma is the most common extracranial solid tumor in childhood. As the prognosis of high-risk neuroblastoma with disseminated disease is still poor, it is of utmost importance to investigate additive novel therapeutic strategies for this disease.

We have previously investigated the role of several enzymes that are modulated by HIF-1α and are up-regulated in the hypoxic microenvironment. Our research indicates that the hypoxic factors in the tumor's microenvironment further the progression of tumor disease, which strengthens the perspectives for additive novel therapeutic approaches targeted hypoxia-dependent factors in neuroblastoma.

Only available in German

 

Group members

  • Stefanie Volkart, MD
  • Zihe Huo, PhD student
  • Urs Kym, MSc
  • Nicola Pini, MD student
 

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0900 712 713

(3.12 CHF/min. prepaid cell phones, possibly additionally 8 Rp. / min. by network operator)

Site Map

Contact

University Children’s Hospital Basel
Spitalstrasse 33
4056 Basel / Switzerland

T +41 61 704 12 12
F +41 61 704 12 13

 

Emergency

Contact

University Children’s Hospital Basel
Spitalstrasse 33
4056 Basel / Switzerland

T +41 61 704 12 12
F +41 61 704 12 13

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