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Emergency Contact 24h

0900 712 712

(3.23 CHF / min. from the Swiss landline, possibly additionally 8 Rp. / min. by network operator)

 
 

0900 712 713

(3.12 CHF / min. for calls from prepaid cell phones, possibly additionally 8 Rp. / min. by network operator)


Important Numbers

  • 144   Ambulance
  • 145   Tox Center (Poisoning)
  • 117   Police
  • 118   Fire Department

Kontakt Box

UKBB

University Children’s Hospital Basel
Spitalstrasse 33
4056 Basel
Switzerland

T +41 61 704 12 12
F +41 61 704 12 13

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For making an appointment or the postponement of an appointment, please contact polyclinic head office +41 61 704 12 20

 
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Pediatric Immunology Research

The focus of the research of the Laboratory of Pediatric Immunology is to delineate the molecular and cellular pathways that govern regular thymus organogenesis and function. Specifically, the lab is interested in:

  • the genetic and epigenetic control of thymic epithelial cell (TEC) differentiation and function,
  • the phenotypic nature and developmental potential of fetal and adult TEC precursor cells,
  • the molecular profile of mature cortical and Aire-expressing medullary TEC

Using gene targeting we have generated unique tools that allow compartment-specific, experimental gain- and loss-of-function models in mice to interrogate aspects of thymus development and function at the cellular and molecular level.

A special interest of our research is focused on studying the role of specific transcription factors such as Foxn1 and understanding the epigenetic "code" that determine the regulatory principles operative in TEC biology. Taking advantage of different molecular methods integrating imaging, flow cytometry, spatial transcriptomics and epigenomics, we analyze specific TEC subpopulations at distinct developmental stages in health and disease. Numerical, structural and functional changes in TEC are related to to the ability to maintain regular immunological functions, in particular the establishment and maintenance of immunological tolerance.

Main projects: Thymic epithelial cell (TEC) development and function

  • The role of the transcription factor Foxn1 in thymic epithelial cell lineage commitment and function.
  • The role of specific miRNA in TEC differentiation and function.
  • The role of epigenetics in TEC differentiation into distinct lineages and their competence to promiscuously express protein-coding genes.

The research group has a "Sister laboratory" at the Weatherall Institute for Molecular Medicine, University of Oxford, United Kingdom

Only available in German

 

Group members

  • Thomas Barthlott, PhD in Molecular Biology
  • Elli Christen
  • Martha Gaio
  • Sanjay Gawade, PhD
  • Katrin Hafen
  • Carlos Mayer, PhD
  • Rodrigo Recinos
  • PD Gabor Szinnai, MD, PhD
  • Hongying Teh
  • Saulius Zuklys, PhD in Immunology
 

Emergencies

0900 712 712

(3.23 CHF/min. CH-landline, possibly additionally 8 Rp. / min. by network operator)

0900 712 713

(3.12 CHF/min. prepaid cell phones, possibly additionally 8 Rp. / min. by network operator)

Site Map

Contact

University Children’s Hospital Basel
Spitalstrasse 33
4056 Basel / Switzerland

T +41 61 704 12 12
F +41 61 704 12 13

 

Emergency

Contact

University Children’s Hospital Basel
Spitalstrasse 33
4056 Basel / Switzerland

T +41 61 704 12 12
F +41 61 704 12 13

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