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Pediatric Infectious Diseases and Vaccinology | Ulrich Heininger

Tuberculosis (TB) in children

Nicole Ritz’s research focuses on enhancing current strategies to diagnose and prevent tuberculosis (TB) in children. This includes immunodiagnostic tests including interferon gamma release assays (IGRA), novel cytokine-based assays and other biomarkers for early detection of childhood TB. Her research interest also focuses on Bacille-Calmette-Guérin (BCG) vaccine the only currently licenced vaccine against TB, in particular on specific and non-specific immune response including adaptive and innate immunity.

Improve child health by preventing infectious diseases

Jan Bonhoeffer’s research strives to improve child health by preventing infectious diseases and optimizing treatment through improved diagnostics. His focus is on generating best evidence for benefit-risk assessment of vaccines with a global network of partners and health care databases. He is also investigating strategies to optimize antibiotic use by improving the diagnosis of respiratory tract infections in children.

Pertussis prevention in children

Ulrich Heininger’s main research interest lies in the field of pertussis, a respiratory tract disease caused by the bacterium Bordetella pertussis. He and his national and international collaborators are focussing mainly on the epidemiology and prevention of pertussis by vaccination. Further, Ulrich Heininger is working on the general acceptance and impact of immunization per se amongst the public as well as health care workers.

Main research projects

Study goal: This study aims to measure IgG anti-PT in Asian children aged 10-18 years. This will enable us to identify how many children have evidence of a recent pertussis infection defined by IgG anti-PT above 125 IU/mL and how many children are potentially susceptible to pertussis infection when exposed.

 

  • Timelines: Start: Q3 or 4/2013; Duration: 24 months
  • Financial support: SPMSD, Lyon, France
Image shows a table with all the collaborators
  • Study goal: To monitor the effect of new pertussis immunization recommendations in Switzerland (adolescents, young adults, and pregnant women) on the epidemiology of pertussis in children. This will be done using assessment of hospitalizations due to pertussis in children (0-15 years of age) within the framework of the Swiss Pediatric Surveillance Unit (SPSU).
  • Collaborators: Co-prinicipal investigators: Ulrich Heininger (UKBB) and Jean-Luc Richard (BAG); Further collaborators: all Swiss pediatric hospitals and units (SPSU); Laboratory analyses: IMM; Univ. of Basel
  • Timelines: 01/2013 – 12/2016.
  • Financial support: BAG
  • Epidemiology of tuberculosis in Swiss children
  • Improving the diagnosis of tuberculosis in children: combining cytokine-based immunodiagnosis with direct and indirect detection of Mycobacterium tuberculosis
  • Improving the reading of tuberculin skin tests
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UKBB

Ospedale pediatrico universitario di Basilea
Spitalstrasse 33
4056 Basilea | CH

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