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0900 712 712
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0900 712 713
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University Children’s Hospital Basel
T +41 61 704 12 12
F +41 61 704 12 13
The clinical scientific studies in the field of pediatric endocrinology and diabetology focus on growth hormones, thyroid disease and diabetes (Prof. Urs Zumsteg and Gabor Szinnai, MD, PhD). Basic research projects are investigating molecular mechanisms of congenital hypothyroidism and thyroid development.
The pediatric diabetology research group consists of clinical staff members including the diabetes nurse team. The clinical research focus lies on clinical application of new technologies in the treatment of Type 1 diabetes mellitus. Metabolic control in general, ketoacidosis, hypoglycemias and activity as well as insulin resistance in adolescents are our main topics, cystic fibrosis-related diabetes is a subject we are working on together with the UKBB pneumologists. The following topics are currently under investigation:
In a prospective observational study, hypoglycemia frequency was analyzed in correlation to physical activity by continuous glucose monitoring and accelerometry during a 6-day-period. This study revealed a unexpectedly high number and long duration of asymptomatic prolonged nocturnal hypoglycemias in 51 children and adolescents. The results stressed the importance of intensified and individualized patient education in the context of physical activity. In a new study approach we plan to investigate heart rate fluctuation under normo- and hypoglycemic conditions (Dr. med. S. Bachmann, MD in collaboration with Prof. Birgit Donner, MD).
This prospective observational study aims at describing in detail the dynamics of water regulatory hormones at diagnosis and during 48 hours of rehydration and insulin therapy in patients with diabetic ketoacidosis to develop algorithms for early detection of overhydration and risk for diabetic ketoacidosis associated cerebral brain edema in children (Dr. med. Svetlana Beglinger, MD and PD Dr. med. Gabor Szinnai, MD, PhD)
This retrospective statistical analysis of anthropometric parameters as reliable indicators of metabolic health problems in overweight and obese children and adolescents is underway to extend the clinical knowledge on early parameters indicating impaired glucose metabolism and type 2 diabetes in childhood (Dr. med. Cristina Pizzagalli, MD).
Furthermore there are several medical master thesis projects running which in part are more quality control related or outcome studies of the new technologies in smaller patient subgroups.
Only available in German
Prof. Dr. med. Urs Zumsteg ist Chefarzt der ambulanten Medizin und Leiter der Pädiatrischen Endokrinologie im UKBB.
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