Pediatric Diabetology Research

In a prospective observational study, hypoglycemia frequency was analyzed in correlation to physical activity by continuous glucose monitoring and accelerometry during a 6-day-period. This study revealed a unexpectedly high number and long duration of asymptomatic prolonged nocturnal hypoglycemias in 51 children and adolescents. The results stressed the importance of intensified and individualized patient education in the context of physical activity. In a new study approach we plan to investigate heart rate fluctuation under normo- and hypoglycemic conditions (Dr. med. S. Bachmann, MD in collaboration with Prof. Birgit Donner, MD).

This prospective observational study aims at describing in detail the dynamics of water regulatory hormones at diagnosis and during 48 hours of rehydration and insulin therapy in patients with diabetic ketoacidosis to develop algorithms for early detection of overhydration and risk for diabetic ketoacidosis associated cerebral brain edema in children (Dr. med. Svetlana Beglinger, MD and PD Dr. med. Gabor Szinnai, MD, PhD)

This retrospective statistical analysis of anthropometric parameters as reliable indicators of metabolic health problems in overweight and obese children and adolescents is underway to extend the clinical knowledge on early parameters indicating impaired glucose metabolism and type 2 diabetes in childhood (Dr. med. Cristina Pizzagalli, MD).